Improvement in Preparation Technique of Rifampicin Eye Drops
- VernacularTitle:利福平滴眼液制备方法的改进
- Author:
Kaihua FAN
;
Jun LOU
;
Xiuyu CHEN
;
Haifeng WANG
- Publication Type:Journal Article
- Keywords:
Rifampicin;
Eye drops;
Neutralization reaction;
Improvement
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a simple and rapid preparation technique of Rifampicin eye drops.METHODS:The calculating quantity of hydrochloric acid was used to dissolve Rifampicin,then the equimol quantity of potassium hydroxide was added to neutralize the acid and yield potassium chloride,whose quantity was designed according to the prescrip?tion.RESULTS:Neutralization reaction not only overcame the difficulty of Rifampicin's dissolution in water,but also avoided the irritation to eyes caused by using ethanol as solvent.CONCLUSION:The method is well-versed in design,simple in preparation and controllable in quality.
