Association of HLA-A Alleles with Systemic Lupus Erythematosus
- VernacularTitle:系统性红斑狼疮与HLA-A等位基因相关性的研究
- Author:
Shaobin XU
;
Yufen TAO
;
Zhengtao CHU
;
Xiaoqin HUANG
;
Guihong BAN
;
Jiankun YU
;
Jiayou CHU
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
Genes, MHC class I;
Polymerase chain reaction-sequence specific primer
- From:
Chinese Journal of Dermatology
1995;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential association of HLA-A alleles and genetic susceptibility with systemic lupus erythematosus (SLE). Methods Polymerase chain reaction-sequence specific primer (PCR-SSP) was used to analyze the distribution of HLA-A alleles among 106 patients with systemic lupus erythematosus and 122 healthy persons. Results Nineteen out of twenty-four kinds of HLA-A alleles were found from the specimens, including 18 kinds in SLE specimens, and 15 kinds in control specimens. Among them, HLA-A*11 allele was positively associated with SLE (RR = 2.4380, EF = 0.1502, ?2 = 12.2440, P = 0.0005, Pc = 0.0095). For A*01 and A*24, although the P values were less than 0.05, the Pc values were more than 0.05 (0.9462 or 0.2356, respectively). Conclusions The results indicate that HLA-A*11 may be the susceptible allele or may be closely linked with the susceptible genes in Chinese SLE patients.
