Association of the E-selectin polymorphism with Systemic Lupus Erythematosus in the Ethnic Zhuang population from Guangxi Province
- VernacularTitle:E选择素基因多态性与广西壮族系统性红斑狼疮的相关性研究
- Author:
Yan LAN
;
Yesheng WEI
;
Shiku DU
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
E-selectin;
Polymorphism, restriction fragment length
- From:
Chinese Journal of Dermatology
1995;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of E-selectin polymorphisms in Guangxi ethnic Zhuang population and the association of E-selectin gene polymorphism in exon 2 and in exon 4 with systemic lupus erythematosus(SLE). Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to study the E-selectin polymorphisms in 82 patients with SLE and 95 healthy controls of ethnic Zhuang population in Guangxi Province. Results The frequencies of GG?GT?TT genotypes in the exon 2 of E-selectin were 86.6%,12.2%, and 1.2% in SLE group; 90.5%, 8.4%, and 1.1% in the control group, respectively. The frequencies of AA?AC?CC genotypes in the exon 4 and E-selectin were 81.7%,15.9%, and 2.4% in SLE group; 92.6%,7.4%, and 0.0% in the control group, respectively. There was a significant difference in the frequencies of allele and genotype in E-selectin A561C polymorphism between SLE group and control group(P
