Expression of HFGL2/ Fibroleukin in Peripheral Blood Mononuclear Cell in Patients with Systemic Lupus Erythematosus and Its Clinical Significance
- VernacularTitle:人纤维介素在系统性红斑狼疮患者外周血单一核细胞中的表达及意义
- Author:
Xiaofeng YAN
;
Yating TU
;
Nengxing LIN
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, Systemic;
hfg12 prothrombinase/fibroleukin;
gene expression
- From:
Chinese Journal of Dermatology
1995;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between procoagulation of HFGL 2 and abnormality of coagulation in patients with systemic lupus erythematosus (SLE) by detecting the expression of HFGL2/fibroleukin in peripheral blood mononuclear cell(PBMC) of SLE patients. Methods A polyclonal antibody against HFGL2 was applied to detecting the expression of HFGL2 protein in 32 SLE patients and 15 healthy volunteers by immunohistochemistry. Semi-quantitative measurement of HFGL2 expression in the blood specimen was done with high multiple image analytical system(HMIAS). Results The expression of HFGL2 in PBMC from 23 active SLE patients was significantly higher than that in the controls, which showed a positive correlation with the disease activity. Conclusion The expression of HFGL2 in PBMC is probably correlated with the pathogenesis and disease activity of SLE.
