Expression of Vascular Endothelial Cell Growth Factor and nm23, Microvessel Density in Lesions of Malignant Melanoma
- VernacularTitle:恶性黑素瘤血管内皮细胞生长因子和nm23抑癌基因蛋白表达及微血管密度的研究
- Author:
Xiuying ZHANG
;
Dong LAN
;
Chunguang TONG
;
Shaowei CHENG
- Publication Type:Journal Article
- Keywords:
Endothelial growth factors;
Melanoma;
Oncogene proteins
- From:
Chinese Journal of Dermatology
1995;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of vascular endothelial cell growth factor (VEGF), nm23 and microvessel density (MVD) in the pathogenesis of malignant melanoma(MM). Methods The specimens from forty-seven cases of malignant melanoma and 10 cases of melanocytic nevus were examined for VEGF, nm23 and CD34 by immunohistochemistry. The density of microvessels was calculated. Results Positive VEGF expression rate and MVD in malignant melanoma were significantly higher than those in melanocytic nevus(both P
