Clinical Study on Sodium Cantharidate Combined with 5-Fu and CF Treatment of Advanced Colorectal Cancer
- VernacularTitle:奇宁联合氟脲嘧啶、亚叶酸钙治疗晚期大肠癌的临床研究
- Author:
Haijin CHEN
;
Aiguo WU
- Publication Type:Journal Article
- Keywords:
Advanced colorectal cancer;
Sodium cantharidate;
CF;
5-FU;
Combination chemotherapy
- From:
Journal of Chinese Physician
2002;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and toxicity of in patients with advanced colorectal cancer. Methods Seventy-six patients were enrolled in this study.38 patients(treatment group)received chemotherapy regimen of sodium cantharidate 0 3mg,CF 200mg/m 2, and 5-Fu 375mg/m 2 intravenous infusion from the first day to the tenth day. 38 patients(control group)received chemotherapy regimen of CF 200mg/m 2 and 5-Fu 375mg/m 2 intravenous infusion from the first day to the tenth day. ALL patients underwent two cycles of the therapy at least. Results The efficacy of the treatment group and control group was 39 5% and 18 4% respectively, which had a significant difference. The hematologic toxicities in the treatment group, especially leukopenia and anemia, were significantly than those in the control group less. Conlusion The results indicated that sodium cantharidate combined with 5-FU and CF treatment of colorectal cancer had moderate activity and less toxicity, further clinical investigation of which should be performed.
