Effects of Smog and Elastase on the Pathogeny of Obstructive Emphysema in Rabbits
- VernacularTitle:烟雾与弹性蛋白酶联合应用对兔阻塞性肺气肿形成的影响
- Author:
Qunyou TAN
;
Ruwen WANG
;
Yaoguang JIANG
- Publication Type:Journal Article
- Keywords:
Rabbit;
Emphysema,obstructive;
Disease models;
Smog;
Elastase
- From:
Journal of Chinese Physician
2002;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of smog and elastase on the pulmonary functions and histology during the pathogeny of rabbits' chronic obstructive pulmonary emphysema. Methods Forty-eight New Zealand rabbits were divided into smoking, elastase, combined and control groups,and given smog produced from cigarette or injected elastase into trachea. Seven weeks later, pulmonary functions, artery blood gas analysis and pulmonary histology were detected. Results Compared with control group, vital volume (V T),forced expiratory volume in 0 3 second (FEV 0 3 ),FEV 0 3 /FVC (forced expiratory capacity), PaO 2,PaCO 2,total lung capacity (TLC),functional residual capacity (FRC), density of alveolar septum (Ds), number of alveolus (Na) and diameter of alveolus (Da) in both elastase (P0 05). Morphological changes of obstructive emphysema were noticed under naked eyes and optical microscope in combined group, while only slight changes could be seen in elastase group. No above change was observed in smoking group. Conclusions Rabbits' obstructive pulmonary emphysema can be induced by elastase, and smog can increase its induction and formation.
