Studies on Mechanism of Saponin of Litchi in Reversing Dexamethasone-induced Insulin Resistance in Rats
- VernacularTitle:荔枝核皂苷改善地塞米松致大鼠胰岛素抵抗作用机制研究
- Author:
Jiewen GUO
;
Wanjun XIE
- Publication Type:Journal Article
- Keywords:
saponin of Litchi;
dexamethasone;
insulin resistance;
hypercortisolism;
hyperinsulinemia
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the mechanism of saponin of Litchi(Sap.Lit)in reversing dexamethasone(DX)-in?duced insulin resistance(IR)in rats.METHODS:With DX-induced insulin resistant rat model,serum levels of total cholesterols(TC),triacylglycerol(TG),cortisol(Cort),fasting glucose(FSG),insulin(Fins),and index of insulin sensitivity(ISI)were detected2h after administration of drug.RESULTS:Sap.Lit reduced the levels of TC,TG,Cort,FSG,Fins(P
