Effect of Calcium Dobesilate on Renal Oxidative Stress in Type2 Diabetic Rats
- VernacularTitle:羟苯磺酸钙对2型糖尿病模型大鼠肾脏氧化应激的影响
- Author:
Quankun XIE
;
Xiaocheng LIU
- Publication Type:Journal Article
- Keywords:
calcium dobesiltae;
diabetic nephropathy;
oxidative stress
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate effect of calcium dobesilate on renal oxidative stress in type2diabetic rats.METHODS:30rats were divided into3groups of normal rats,diabetic rats,diabetic rats treated with calcium dobesi?late.Content of malonaldehyde(MDA)and activity of antioxidant enzymes including superoxide dismutase(SOD),glutathione peroxidase(GSH-PX)in the renal tissue were compared among the groups.In addition,blood glucose,serum creatinine(Cr),blood urea nitrogen(BUN)were measured;the renal tissue were observed by light microscopy and electron microscopy.RESU_ LTS:Compared with untreated group,the level of BUN,Cr,renal MDA in calcium dobesilate treated group were significantly decreased,but the activity of renal SOD,GSH-PX were increased notably.In addition,the renal pathologic changes in calcium dobesilate treated group was also improved.CONCLUSION:Oxidative stress takes key point in the development of diabetic nephropathy,and antioxidation may be the possible mechanism of the neohroprotective action of calcium dobesilate.
