Determination of Two Ingredients in Calamine and Menthol Lotion by GC-MS
- VernacularTitle:气相色谱-质谱法测定炉甘石薄荷脑洗剂中2组分的含量
- Author:
Zhengzhong WU
;
Jiying YU
;
Lin HE
;
Shiming SUN
- Publication Type:Journal Article
- Keywords:
GC-MS;
phenol;
menthol;
content
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a GC-MS assay for determination of the contents of phenol and menthol in calamine and menthol lotion.METHODS:Using DM-5elastic quartz capillary as separation column,I-octanol as internal standard,phenol and menthol were detected separately under the70℃～150℃step-up hyperthermic condition to select the ion fragment peaks with M/Z of94and71.RESULTS:Phenol and menthol were good linear within1.092～21.840?g/ml(r=0.9998)and1.194～9.552?g/ml(r=0.9999).Recoveries were100.2%(RSD=1.34%)and100.4%(RSD=0.74%)respective?ly.CONCLUSION:The method is quick and accurate with highly repeatability and specificity and it is adequate for contents determination and quality control for this preparation.
