Effects of Ligustrazine Injection on DNA Synthesis of Vascular Endothelial Cell
- VernacularTitle:川芎嗪注射液对血管内皮细胞DNA合成的影响
- Author:
Lirong YANG
;
Xiaoyu XU
;
Gang CHEN
- Publication Type:Journal Article
- Keywords:
Ligustrazine injection;
3 H-TdR;
vascular endothelial cell;
DNA synthesis
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of ligustrazine injection(LTZ)on DNA synthesis of vascular endothelial cell.METHODS:In vitro cultured cell line of human umbilical vein endothelial cells,ECV304,were adopted to measure the ef?fects of LTZ on DNA synthesis by 3 H-TdR incorporation.RESULTS:LTZ could inhibit DNA synthesis of ECV304in a dose-dependent manner.CONCLUSION:The mechanism of anti-angiogenesis of LTS might be associated with inhibiting DNA synthesis of vascular endothelial cell.
