Changes of potassium currents in rabbit ventricle with healed myocardial infarction
- VernacularTitle:家兔陈旧性心肌梗死心室肌细胞钾离子电流的变化
- Author:
Nian LIU
;
Huiyan NIU
;
Yang LI
;
Cuntai ZHANG
;
Qiang ZHOU
;
Yanfei RUAN
;
Jun PU
;
Zaiying LU
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Potassium channels;
Patch clamp techniques
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To elucidate the mechanism of arrhythmia in healed myocardial infarction (HMI), and to investigate the changes of action potential duration (APD),transient outward potassium current (I to ), delayed rectifier potassium current (I K) and inward rectifier potassium current (I K1 ) of left ventricular myocytes in noninfarcted zone of HMI. METHODS: 12 rabbits were randomly assigned in two groups: HMI group (thoracotomy and ligation of the circumflex coronary); sham-operated group (thoracotomy but no conorary ligation). 3 months after operation, whole cell patch clamp technique was used to record APD, I to , I K and I K1 of ventricular myocytes in non-infarcted zone. RESULTS: Membrane capacitance was larger in HMI group than that in sham-operated group. Action potential duration was lengthened significantly in HMI group and early after depolarization (EAD) appeared in HMI group. The densities of I to , I K,tail and I K1 were reduced significantly in HMI group (P
