Effect of autologous bone marrow mononuclear cell local transplantation on peripheral neovascularization
- VernacularTitle:自体骨髓细胞局部移植对外周血管新生作用的影响
- Author:
Chaorong HE
;
Qunlin ZHANG
;
Yi HE
;
Yanbing LI
;
Weimin WANG
;
Chongquan WANG
;
Zhenghua ZHANG
;
Jianhua YI
;
Congxin HUANG
- Publication Type:Journal Article
- Keywords:
Bone marrow transplantation;
Neovascularization, pathologic;
Ischemia
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of autologous bone marrow mononuclear cells (BM-MNCs) local transplantation (BM-LT) on a rabbit model of hindlimb ischemia. METHODS: After unilateral femoral artery and its branches were surgically ligated and excised in rabbits (n=14) 1 hour or so, autologous BM-MNCs were injected into the ischemic skeletal muscles in 7 rabbits, and phosphate buffered saline for another 7 ones as control. Hemodynamics parameters were measured at day 0, day 7 and day 28, respectively. On day 28, the animals were sacrificed in groups for pathological analysis. RESULTS: Compared with control group, color Doppler flow image in BM-LT group was recovered significantly, and its' systolic peak velocity and end-diastolic velocity were also improved (P
