Antioxidant status and oxidatvie damage in patients with Graves' disease
- VernacularTitle:格雷夫斯病患者体内抗氧化状态及氧化损伤的研究
- Author:
Weiming SUN
;
Xulei TANG
;
Xiaoju LIU
;
Jin ZHAO
;
Wei LIU
- Publication Type:Journal Article
- Keywords:
Graves' disease;
Oxidative stress;
Malondialdehyde;
DNA damage
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the antioxidant status and the oxidative damage of cellular macromolecules in patients with Graves' disease. METHODS: Fasting plasma level of total antioxidant capacity (TAC), and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured in 31 patients with untreated Graves' disease and 31 treated Graves' disease. DNA damage of peripheral blood mononuclear cell (PBMC) was detected by single cell gel electrophoresis assay (expressed in comet percentage). In addition, thiol group (SH) and malondialdehyde (MDA) were measured. 31 age-matched healthy subjects were studied as a control group. RESULTS: Plasma TAC, SOD and GSH-Px were significantly lower in patients with untreated Graves' disease compared to the controls (P
