Changes of related proteins of neural stem cell differentiation and proliferation in rats treated with corticosterone
- VernacularTitle:神经干细胞增殖分化相关蛋白在皮质酮大鼠中的变化
- Author:
Chang GAO
;
Jinzhou WANG
;
Weikang WU
- Publication Type:Journal Article
- Keywords:
Corticosterone;
You Gui-Yin;
Neural stem cells;
Notch;
bHLH
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the changes of related proteins of neural stem cell differentiation and proliferation in rats treated with corticosterone (CORT). METHODS: Western blot method was used to investigate the changes of related protein of neural stem cell differentiation and proliferation. RESULTS: Compared with the normal control group, related proteins (Notch1, hes5, Mash1 and NeuroD) of neural stem cell differentiation and proliferation were significantly decreased in the CORT rats on the day 30 and 60, especially for Mash1 and NeuroD (P
