Effect of ovariectomization on Alzheimer-like phosphorylation of Tau in hippocampus of rats
- VernacularTitle:去势雌性大鼠海马区Tau蛋白Alzheimer样磷酸化的变化
- Author:
Qi ZHANG
;
Maoqiong HU
;
Xiaoyan DAI
;
Yi LIU
;
Jianzhi WANG
- Publication Type:Journal Article
- Keywords:
Estrogen;
Alzheimer disease;
Tau proteins;
Rats;
Hippocampus
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of ovariectomization on Alzheimer-like phosphorylation of Tau in hippocampus of Sorague-Dawlery rats. METHODS: An animal model was developed using ovariectimized (OVX) rats, and the phosphorylation of Tau protein was measured by Western blot. RESULTS: The levels of phosphorylated Tau at PHF-1epitope were elevated in ovariectimized rat brain hippocampus 4 weeks and 8 weeks after ovariectomization, when compared with sham-OVX rats (P0.05). CONCLUSION: Ovariectomization may induce Alzheimer-like hyperphosphorylation of Tau protein in brain hippocampus of rats. [
