Expression of TFF3 mRNA in the lung tissue in COPD rats
- VernacularTitle:肠三叶因子mRNA在慢性阻塞性肺疾病大鼠肺组织中的表达
- Author:
Yong LIN
;
Yujian TAO
;
Siqing SUN
;
Feng HUA
- Publication Type:Journal Article
- Keywords:
Lung diseases, obstructive;
Models, animal;
Intestinal trefoil factor
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To elucidate the change in TFF3 mRNA in the lung tissue in chronic obstructive pulmonary disease (COPD) rats. METHODS: A model of rat COPD was established by passive cigarette smoking and intratracheal instillation of lipopolysaccharide. The expression of TFF3 mRNA in the lung tissues was detected by reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: Through a semi-quantitative pathological analysis, mean lung internal lining interval (MLI) in COPD model group was significantly increased compared with healthy control groups; mean alveolar number (MAN) in COPD model group was significantly decreased compared with healthy control group. The expression of TFF3 mRNA decreased significantly in the lung tissue in COPD model group compared with healthy control group. CONCLUSION: The level of TFF3 mRNA expression is possibly related with lung tissue lesion in COPD rats. [
