Recent progresses in endotoxin-induced p38 MAPK signal transduction
- VernacularTitle:内毒素诱导p38 MAPK信号转导作用的研究进展
- Author:
Lin YAO
;
Shuqin YU
;
Xiran ZHANG
- Publication Type:Journal Article
- Keywords:
Lipopolysaccharides;
Mitogen-activated protein kinase p38;
Inflammation mediators;
Signal transduction
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
A Review The diseases caused by endotoxin have seriously affected human health. Previous studies have shown that p38 MAPK pathway is involved in the intracellular signal transduction induced by lipopolysaccharide (LPS), which plays an important role in the activation of inflammation-related cells to release inflammation mediator. Recently there have been some progresses in the isoforms distribution, substrate, molecular mechanism of regulating the release of inflammatory mediators, cellular specific activation and levels of p38 MAPK. [
