The Effect of Jianweiyuyang Granule on Gastric Ulcer and Expression of VEGF and PDGF in Rat
- VernacularTitle:健胃愈疡颗粒剂对大鼠胃溃疡的影响及VEGF和PDGF表达的变化
- Author:
Xingping DAI
;
Jiabang LI
;
Bing ZHOU
- Publication Type:Journal Article
- Keywords:
Jianweiyuyang granule;
Gastric ulcer;
Ulcer index;
VEGF;
PDGF;
Rat
- From:
Journal of Chinese Physician
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Jianweiyuyang(JWYY) granule on gastric ulcer of rats and its effective mechanism. Methods The rat model of gastric ulcer was set up by Okeba's method with some modification, and the expression of vascular endothelial growth factor (VEGF) and platelets-derived growth factor (PDGF) in the gastric ulcer tissues was examined by immunohistochemical method. Results JWYY granule could elevate the expression of both VEGF and PDGF, obviously decrease the ulcer index, increase the thickness of gastric mucosa, and promote the healing of gastric ulcer. Conclusion The results indicated that Jianweiyuyang granule can increase the expression of VEGF and PDGF, which may be one of the mechanism of its promoting the healing of the gastric ulcer.
