Expression and Clinical Signficance of Survivin and PCNA in Nasopharyngeal Carcinoma
- VernacularTitle:Survivin蛋白和PCNA在鼻咽癌中的表达及其临床意义
- Author:
Jibin ZOU
;
Guangen HUANG
;
Zhongjian CHEN
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal carcinoma;
Survivin;
PCNA;
Prognosis;
Immunohistochemistry
- From:
Journal of Chinese Physician
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and clinical significance of survivin protein and proliferation cell nuclear antigen(PCNA) in human nasopharyngeal carcinoma (NPC). Methods The expression of survivin protein and PCNA was detected by SP immunohistochemical technique in 96 cases of NPC tissues. Results The positive rate of survivin expression was 75.0% in PNC. Labeling idex(LI) of PCNA in survine positive NPC was higher than that in survivin negative NPC. The positive rate of survivin expression in NPC with neck lymph node metastasis was higher than that in NPC without neck lymph node metastasis. The positive rate of survivin expression in NPC patients with less than 5-year survival rate was higher than that in NPC patients with over 5-year survival rate. Conclusion NPC had survivin expression, and survivin expression in NPC was positive related with PCNA expression. The survivin protein might promote the neck lymph node metastasis of NPC cells. The prognosis of the patients with survivin positive NPC was worse.
