The Protective Effect of Ulinastatin on Myocardial Reperfusion Injury during Cardiopulmonary Bypass in Patients Underwent Valve Replacement
- VernacularTitle:乌司他丁对心脏瓣膜置换术患者围术期心肌缺血再灌注损伤的保护作用
- Author:
Liwen LI
;
Li LI
;
Jinmei SHEN
- Publication Type:Journal Article
- Keywords:
Ulinastatin;
Valve replacement;
Myocardial reperfusion injury;
cTnI
- From:
Journal of Chinese Physician
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of ulinastatin on myocardial reperfusion injury during cardiopulmonary bypass(CPB) in patients underwent valve replacement. Methods 26 ASA Ⅱ-Ⅲ patients scheduled for valve replacement were randomly divided into control group (group C) and ulinastatin group ( group W), each group containing 13 patients. In group W, the patients received ulinastatin 12000U?kg -1 , half dose of which was given before CPB, and the other half was added into the primary solution. Plasma levels of CK,CK-MB and cTnI were measured before operation(T 1), 20 min after starting CPB(T 2), 30 min after declamping aorta (T 3), and 4h(T 4) and 24h(T 5) after operation. Results The plasma level of CK, CK-MB and cTnI increased significantly at T 3, T 4 and T 5 in the both groups compared with T 1(P
