The Level Change and Clinical Significance of Serum IL-6, IL-8 and IL-13 in the Patients with Lupus Nephritis
- VernacularTitle:狼疮性肾炎患者血清三参数水平变化及意义
- Author:
Hong CAO
;
Jingguo ZHOU
;
Zhong TANG
- Publication Type:Journal Article
- Keywords:
Lupus nephritis;
Interleukin-6;
Interleukin-8;
Interleukin-13
- From:
Journal of Chinese Physician
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level change and clinical significance of serum IL-6, IL-8 and IL-13 in the patients with lupus nephritis(LN). Methods The levels of serum IL-6,IL-8 and IL-13 were measured by enzyme linked immunosorbent assay (ELISA) in 56 patients with LN. Results The levels of serum IL-6,IL-8 and IL-13 in the patients with active LN were significantly higher than those in the patients with non-active LN and the controls, but had no significant difference between the patients with non-active LN and controls. The levels of serum IL-6,IL-8 and IL-13 in the patients with active LN were positively correlated with anti-dsDNA antibody titre and erythrocyte sedimentation rate, but negatively correlated with the serum levels of complements C 3 and C 4. Conclusion IL-6,IL-8 and IL-13 may be involved in the pathogenesis of lupus nephritis, can serve as a clinical reference index for activity of LN, and have important clinical significance in guiding LN therapy and improving LN prognosis.
