Roles of Foxc2 in the development of axial skeleton
- VernacularTitle:叉头框c2在中轴骨骼发育过程中的作用
- Author:
Yan FU
- Publication Type:Journal Article
- Keywords:
Genes, Foxc2;
Skeleton;
Dysostoses
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the roles of forkhead box c2(Foxc2) in axial skeloton. METHODS: Mice lacking Foxc2 locus were produced by targeted mutation and the developmental anomalies in axial skeleton were analyzed. RESULTS: Foxc2 protein increased markedly in Myoblasts C2C12 after treating with BMP-2, and alkaline phosphatase activity and production of osteocalcin in Myoblasts C2C12 were significantly higher than that in cell lines transfecting antisense Foxc2 sequence. Expressed median cleft palatine, dysplasia of auditory ossicles and vertebral and anteroposterior facial dysplasia were found in all 15 homozygous mouse neonates with targeted mutation of Foxc2. CONCLUSION: These results suggest that Foxc2 has indispensable roles during skeletogenesis in mesoderm and cells derived from the neural crest. [
