Expression of vascular endothelial growth factor and tumor necrosis factor-alpha in synovium of rats with adjuvant arthritis
- VernacularTitle:血管内皮生长因子与肿瘤坏死因子-?在佐剂关节炎大鼠滑膜中表达
- Author:
Jinrong WANG
;
Xiuzhen HAN
;
Yongkang WANG
;
Xiaoxia L
;
Hongwei WANG
;
Bo HAN
;
Jianxin ZHUANG
;
Yuzhen YANG
- Publication Type:Journal Article
- Keywords:
Endothelial growth factors;
Tumor necrosis factor;
Synovial membrane;
Arthritis, experimental;
Arthritis, rheumatoid
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of vascular endothelial growth factor (VEGF) and tumor necrsis factor-alpha (TNF-?) in synovium of rats with adjuvant arthritis (AA) and the relationship between the pathological score and the expression of VEGF and TNF-? protein. METHODS: AA was produced in Wistar rats by inoculating complete Freund's adjuvant (CFA). The arthral pathological score was calculated, production of VEGF and TNF-? protein were assayed by histoimmunochemical staining at different stage after CFA inoculation. RESULTS: In AA group, the pathological score and expression of VEGF protein in synovium increased significantly (P
