Transcription and expression of endothelin-1 and endothelin A receptor in lung after mustard intoxication
- VernacularTitle:芥子气中毒后肺组织内皮素-1及内皮素A受体的含量和转录表达的研究
- Author:
Xia CAO
- Publication Type:Journal Article
- Keywords:
Mustard gas;
Endothelin-1;
Receptor, endothelin;
Lung
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the role of endothelin-1 (ET-1), endothelin A receptor (ETAR) in pathophysiology of the lung after mustard intoxication. METHODS: The changes of transcription and expression of ET-1 and ETAR in the lung and their relationship with the tissue damage were studied with immunohistochemistry and RT-PCR. RESULTS: The level of ET-1 in the lung was significantly increased at 2 h, but decreased at 12 h after mustard intoxication. The transcription and expressin of ET-1 and ETAR were significantly increased at the early stage after intoxication. mRNA of endothelin-1 was increased, while mRNA of endothelin A receptor was down-regulated after (12 h.) CONCLUSION: ET-1 and ETAR in lung may play important roles in the pathophysiological process of mustard intoxication. [
