Effect of airway remodeling on airway responsiveness in asthmatic guinea pigs
- VernacularTitle:豚鼠哮喘模型气道重建对气道反应性的影响
- Author:
Ting YANG
;
Chen WANG
;
Baosen PANG
;
Kewu HUANG
;
Chengqing XIA
;
Shujie NIU
- Publication Type:Journal Article
- Keywords:
Asthma;
Airway responsiveness;
Airway remodeling
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To establish a guinea pig asthma model and to evaluate the effect of airway remodeling on airway responsiveness. METHODS: The guinea pig asthma model was established by ovalbumin (OVA) sensitization and challenge repeatedly. Bronchial provocation tests were conducted through intravenous injection of acetylcholine. The airway morphologic parameters were measured by computer image analysis system. White blood cells and the differential count in bronchoalveolar lavage fluid (BALF) were examined. RESULTS: The resistance of airway was increased significantly after 4 weeks of OVA exposure, but the increase disappeared upon prolonged exposure. After 8 weeks of OVA exposure, fiber tissue in large airway was increased, and the thickness of smooth muscle layer of small airway was enlarged, as compared with that in control animals. CONCLUSION: Airway responsiveness has changed after prolonged OVA exposure in guinea pigs. This change is related to airway remodeling. [
