Effects of inhibition of Kupffer cell and splenectomy on thioacetamide-induced hepatic injury
- VernacularTitle:封闭枯否细胞和脾切除对急性肝损伤影响的实验性研究
- Author:
Yan ZHAO
;
Jinchun LIU
;
Dewu HAN
;
Ruiling XU
- Publication Type:Journal Article
- Keywords:
Endotoxemia;
Kupffer cells;
Splenectomy;
Liver
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To examine the effects of inhibition of Kupffer cell and splenectomy on intestinal endotoxemia and hepatic injury. METHODS: The hepatic injury model was established by treatment with thioacetamide (TAA). At the same time, inhibition of Kupffer cells by intravenous GdCl_3 and splenectomy were performed. Serum alanine aminotransferase (ALT), TNF-?, endotoxin content and phagocytic index were observed. RESULTS: In the TAA+GdCl_3 group, and TAA+splenectomy group, the endotoxin content was significently higher than that in normal and TAA group (P