Protective effects of basic fibroblast growth factor against myocardial ischemia in rats
- VernacularTitle:碱性成纤维细胞生长因子对大鼠缺血心肌的保护作用
- Author:
Lili LU
;
Jitian CHEN
;
Danfeng WANG
;
Yanbo LIU
;
He GE
;
Fanli KONG
;
Ziqiang LIU
- Publication Type:Journal Article
- Keywords:
Fibroblast growth factor 2;
Myocardial ischemia;
Creatine kinase;
Bcl-2
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protective effects of basic fibroblast growth factor (bFGF) on myocardial ischemia in rats and their underlying mechanism. METHODS: A rat myocardial ischemic injury model was established by left coronary artery ligation. The rats were killed at 2 h, 4 h, 8 h after coronary artery occlusion. The samples of blood and myocardium were collected for observing the expression of Bcl-2 and Bax in myocardial cells and the changes of superoxide dismutase (SOD) or myocardial enzymes. RESULTS: The amount of Bcl-2 protein expression of myocardial cells in ischemia + bFGF group was significantly higher than that in ischemia+saline group (P
