Mechanisms of hepatocytic mitochondria damage following septic shock
- VernacularTitle:败血症休克肝细胞线粒体损伤机制的实验研究
- Author:
Gang YIN
;
Zhiqiang WANG
- Publication Type:Journal Article
- Keywords:
Shock, septic;
Liver;
Mitochondria;
Respiratory control rate;
Adenosinetriphosphatase
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study mechanism of hepatocytic mitochondria damage following septic shock. METHODS: 30 SD rats were randomly divided into three groups: sham operation group, 12 h cecal ligation and puncture (CLP) group and 16 h CLP group. The model of septic shock was made by cecal ligation and puncture. The liver mitochondria respiratory control rate (RCR), phosphate/oxygen (P/O) and ATPase activities were assayed. RESULTS: In 12 h CLP group mean artery pressure (MAP) [(9.54?1.26) kPa] was significantly lower than sham operation group [(14.58?1.32) kPa, P
