Effect of 2,3,5,4'—tetrahydroxystilbene—2—O—?—D—glucoside on the Learning and Memory Ability of Mouse Dementia Models Induced by Scopolamine
- VernacularTitle:何首乌提取物二苯乙烯苷对东莨菪碱致学习记忆障碍模型小鼠的影响
- Author:
Cuifei YE
;
Haifeng WEI
;
Li ZHANG
;
Lan ZHANG
;
Lin LI
- Publication Type:Journal Article
- Keywords:
tetrahydroxystilbene—2—O—?—D—glucoside;
scopolamine;
learning and memory disturbance;
mouse model
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of 2,3,5,4'—tetrahydroxystilbene—2—O—?—D—glucoside(TSG) on the learning and memory ability of mouse dementia models induced by scopolamine METHODS:Mice were randomly divided into blank group,model group,TSG groups(low dose,high dose) and positive control(Piracitam) group All the mouse were intragastrically administrated by drugs After making model,all mice were subjected to Morris water maze and passive avoidance tests RESULTS:Compared with model group,swimming time were significantly reduced in the blank group,positive control group and high dose of TSG group during Morris water maze test (P
