Study on Solid Dispersion of Quercetin
- VernacularTitle:槲皮素聚维酮固体分散体的研制
- Author:
Baohong LI
;
Yifeng DENG
;
Nianci LIANG
- Publication Type:Journal Article
- Keywords:
quercetin;
polyvinyl pyrrolidone;
solvent-volatilization method;
solid dispersion;
solubility
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare solid dispersion for increasing solubility of quercetin METHODS:Using polyvinyl pyrrolidone(PVP) as the carrier,solid dispersion of quercetin was prepared by solvent -volatilization method The solubility of the solid dispersion was detected IR spectrometer and UV spectrometer were used to investigate the physical and chemical properties of the solid dispersion RESULTS:The solubility of solid dispersion was significantly increased compared with quercetin and the physical mixture Quercetin existed as ultrafine crystalline or molecular form in solid dispersion,so there was no chemical reaction between quercetin and PVP CONCLUSION:PVP could be used as the carrier of solid dispersion to increase the solubility of quercetin in water
