Preparation and Quality Control of Slow-released Implantable Adriamycin Tablets
- VernacularTitle:阿霉素-聚乳酸眼用缓释植入片的制备及质量控制
- Author:
Jiaqing FAN
;
Yunshu TU
;
Yong DING
- Publication Type:Journal Article
- Keywords:
adriamycin;
polylactic acid;
slow_released implantable tablet;
preparation;
quality control
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare the slow_released implantable adriamycin tablets and to establish the standard of quality control METHODS:Slow_released implantable adriamycin tablets were prepared with polylactic acid as carrier and were implanted into rabbit’s eyes for observation UV_spectrophotometer was used to determine the content of adriamycin in impla_ntable tablet RESULTS:The average weight of the implantable tablet was 4 56mg The absorption value and concentration showed a good linearity in a range of 0 86～10 72?g/ml(r=0 9 993) The average recovery was 99 20%,RSD=0 43%(n=5) CONCLUSION:The slow_released adriamycin tablet is simple in preparation technic and feasible in quality control method
