Study on Quality Control of Lovastatin Sustained-release Tablets
- VernacularTitle:洛伐他汀缓释片的质量控制研究
- Author:
Tao YI
- Publication Type:Journal Article
- Keywords:
Lovastatin;
sustained-release tablet;
quality control
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the quality control of Lovastatin sustained-release tablets METHODS:The various factors affecting in vitro dissolution were investigated The content of Lovastatin in sustained-release tablets was detected with UV-spectrophotomery RESULTS:The calibration curves of lovastatin was linear from 1 77～10 62?g/ml;The contents of tablets were between 95%～105% It kept releasing for 24h in sodium lauryl sulfate solution at pH=7 0 The releasing rule fitted zero degree dynamic equation and Higuchi equation CONCLUSION:The determination method is simple,accurate and repeatable The method can be used for quality control of Lovastatin Sustained-release tablets
