Hepatic Toxicity of Arsenic Trioxide on Rabbits with Hepatic Vx-2 Carcinoma by Transcatheter Arterial Chemoembolization
- VernacularTitle:三氧化二砷经肝动脉栓塞化疗对肝脏的毒副作用
- Author:
Mingyou ZHENG
;
Xiaodong YU
;
Tao WANG
- Publication Type:Journal Article
- Keywords:
Arsenic trioxide;
Transcatheter arterial chemoembolization;
Liver;
Toxicity
- From:
Journal of Chinese Physician
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate hepatic toxicity of arsenic trioxide(As 2O 3) on rabbits with hepatic Vx-2 carcinoma by transcatheter arterial chemoembolization (TACE), and its clinical signification. Methods New Zealand rabbits with hepatic Vx-2 carcinoma were managed with normal saline (experimental group 1), normal saline plus lipiodol (experimental group 2), and As 2O 3 plus lipiodol (experimental group 3) respectively by TACE once, whereas experimental group 4 was treated with As 2O 3 by transcatheter arterial infusion(TAI) for 7 days consecutively. The morphological changes of the tumor adjancent hepatic tissue were observed under light microscope and transmission electron microscope. The hepatic function of the rabbits was also determined. Results The hepatic cells of the rabbits in the experimental groups 2 and 3 were injuried in various degrees, but the injury extent was smaller than that in the experimental group 4 (P
