The Cytotoxic Effect of ~(103)Pd Particle Radiotherapy Combinded with 41℃ Heating on Human Hepatocarcinoma Cell Line Bel-7402
- VernacularTitle:~(103)Pd粒子联合加热41℃对人肝癌细胞7402细胞毒作用的实验研究
- Author:
Liang YE
;
Ping CHEN
;
Yanmin LIU
- Publication Type:Journal Article
- Keywords:
103Pd particles;
Hepatic cell carcinoma;
Apoptosis
- From:
Journal of Chinese Physician
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the cytotoxic effect of 103 palladium( 103 Pd) particle radiotherapy combined with 41℃ heating on human hepatocarcinoma cell line Bel-7402. Methods Human hepatocarcinoma cells (Bel-7402) were treated by water-heating and/or 103 Pd particle. The cell growth was determined with MTT assay, and the cell apoptosis was detected by the fluorescent stain of Hoechst33258. Results The cytotoxic effect of 103 Pd radiotherapy combinded with 41℃ heating on Bel-7402 cells was stronger than that of only 103 Pd radiotherapy. Conclusion 103 Pd radiotherapy and 41℃ heating had a synergistic effect on hepatocarcinoma cell Bel-7402, and 103 Pd radiotherapy had the cytotoxic effect on the surviving Bel-7402 cells after hot therapy.
