Analysis of In Vitro Antifungal Susceptibility of Vaginal Isolates of Candida spp.
- VernacularTitle:阴道分离的念珠菌体外抗真菌药物敏感性分析
- Author:
Cuihong LIAN
;
Fan CUI
;
Yongnian SHEN
;
Wei CHEN
;
Weida LIU
- Publication Type:Journal Article
- Keywords:
Candidiasis,vulvovaginal;
Candida;
Antifungal agents;
Microbial sensitivity tests
- From:
Chinese Journal of Dermatology
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To analyse the antifungal susceptibility of Candida spp. isolated from the patients with recurrent vulvovaginal candidiasis (RVVC), vulvovaginal candidiasis (VVC) and asymptomatic carriers and to study the correlation between different Candida strains and antifungal susceptibility. Method According to the NCCLS-M27-A scheme, the antifungal susceptibility of Candida spp. isolated from the above different groups was measured. Results Almost all the MICs of C. glabrata and C. krusei to 8 antifungal agents were higher than those of C. albicans. The average MIC of C. albicans isolated from RVVC patients was higher than that from asymptomatic carriers. The resistant strains were mainly isolated from the RVVC group. No resistant strains against itraconazole, fluconazole, ketoconazole, econazole and nystatin was found in asymptomatic carriers. Conclusions These results indicate that more attention has to be paid to the low susceptibility of non-Candida albicans in the treatment of vulvovaginal candidiasis, and the resistant strains may result from long-term or irregular antifungal treatment.
