The Effects of PNS on Alzheimer's Disease Model of Mouse and Mechanism of the Effects
- VernacularTitle:三七总皂苷对痴呆大鼠模型学习记忆行为的影响及其机理探讨
- Author:
Changjie GUO
- Publication Type:Journal Article
- Keywords:
Panax notoginseng saponins;
Alzheimer’s disease;
learning and memory;
acetylcholine
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effects of Panax notoginseng saponins(PNS)on learning and memory ability of ibotenic acid(IBA)-induced Alzheimer’s disease model of mouse and content of acetylcholine(ACh)in hippocam?pus.METHODS:To develop the model by injecting into basalis magnocellularis with IBA.The models were treated with PNS and NS.Learning and memory ability were measured by Morris water maze and content of ACh in hippocampus by spec?trophotometry.RESULTS:PNS can increase learning and memory ability and the content of ACh in hippocampus of model mouse.CONCLUSION:The reduction of learning and memory ability of mouse could be treated with PNS,and the increase of the content of ACh in hippocampus may be one of the mechanism of the effects.
