Association of Fas promoter-670 polymorphism with systemic lupus erythematosus in southern Chinese
- VernacularTitle:中国南方系统性红斑狼疮患者Fas-670基因多态性研究
- Author:
Anping XU
;
Peida YIN
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
Genes, Fas;
Polymorphism
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate whether Fas promoter-670 polymorphism is associated with systemic lupus erythematosus(SLE) in Southern Chinese. METHODS: 103 SLE patients and 110 controls were studied. Fas promoter -670 polymorphism was typed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). RESULTS: No statistically significant differences were found when Fas promoter -670 genotype and allele frequencies were compared between the SLE and the controls. Similarly, no significant differences were seen between the male and female SLE and the controls, the SLE with lupus nephritis (LN) and the controls, the SLE with LN and the SLE without LN. CONCLUSION: Fas promoter -670 polymorphism does not appear to be associated with susceptibility to SLE in Southern Chinese. [
