Alterations in gene expression of sarcoplasmic reticulum Ca~(2+)-ATPase and phospholamban detected by RNA array in spontaneously hypertensive rats
- VernacularTitle:RNA阵列技术检测自发性高血压大鼠肌浆网Ca~(2+)-ATP酶和受磷蛋白基因表达
- Author:
Naiyun CHEN
;
Shenjiang HU
;
Haitao DONG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Rats;
Ca(2+)-transporting ATPase;
Gene expression
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the relationship between the alteration in gene expression of sarcoplasmic reticulum Ca~(2+)-ATPase (SERCA) and phospholamban (PLB) in spontaneously hypertensive rats (SHR). METHODS: 294 samples of total RNA were obtained from the tissue of ventriculum , aortic smooth muscle, liver and kidney in SHR and normotensive rats (WKY). RNA array was used to determine the mRNA levels of SERCA and PLB. RESULTS: Compared with age-matched WKY rats, the systolic blood pressure increased higher in 6-week-old SHR (P
