Effects of non-excitatory electric stimulation on cardiac function in normal and infarcted heart rabbits and it's regional effect on myocardium
- VernacularTitle:非兴奋性电刺激对正常及心肌梗死兔心功能的影响及其作用的局部性
- Author:
Haizhu ZHANG
;
Changcong CUI
;
Xiaojing ZHAO
;
Liquan LEI
;
Jian LIU
;
Jiangfang LIAN
- Publication Type:Journal Article
- Keywords:
Hemodynamics;
Myocardial infarction;
Absolute refractory period;
Electric stimulation;
Rabbits
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the influences of electric stimulation applied during the absolute refractory period (ARP) on the cardiac function of normal rabbits and rabbits after myocardial infarction (MI) and to observe the regional effects of this electric stimulation. METHODS: 64 rabbits were randomly assigned to normal and MI groups and each group was then divided into the anterior and posterior groups. A thoracotomy was performed 4 weeks after MI in rabbits. One set of electrodes was inserted into the anterior and posterior wall of left ventricle of the anterior and posterior groups, respectively. Current pulses were delivered during the ARP (called CCM) during sinus rhythm in rabbits. The left ventricular systolic pressure (LVSP) and the left ventricular end diastolic pressure(LVEDP) as well as maximum positive and negative left ventricular pressure change (?dp/dt_(max)) were observed. RESULTS: In the normal and MI groups, LVSP, +dp/dt_(max) significantly increased, and LVEDP, -dp/dt_(max) were reduced during CCM stimulation compared with the baseline (P0.05). CONCLUSION: Electric stimulation delivered during the ARP significantly enhances the contractility and the relaxation of myocardium in normal rabbits and rabbits after MI, and the effects of CCM stimulation on heart are regional. [
