Effect of Fas ligand gene on reendothelialization in rat carotid artery with balloon withdrawal injury
- VernacularTitle:FasL基因对大鼠颈动脉球囊损伤后内皮再生影响的实验研究
- Author:
Hong TAO
;
Lidong CHEN
;
Congxin HUANG
;
Qunlin ZHANG
- Publication Type:Journal Article
- Keywords:
Fas ligands;
Genes;
Endothelium, vascular;
Regeneration;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of Fas ligand on reendothelialization in the rat carotid artery with balloon withdrawl injury. METHODS: Balloon withdrawal injury was used to establish the denuded carotid artery rat model in twelve SD rats and then six SD rats were treated with ?-gal virus supernatant (?-gal group), and the others were treated with FasL virus supernatant (FasL group). After fourteen days, Evans blue dying was conducted via injection through rat tail vein at 30 min before the animals were killed, then fixation perfusion in situ was performed with 10% formalin and specimens were obtained. Histologic observation and morphometric analysis were made. RESULTS: The reenothelialization area (RA) of arterial balloon injury and the ratio of the reenothelialization area to the total area ((RA/TA)) significantly increased in FasL group compared with those in ?-gal group (P
