Changes of MAPKs expression in rat hippocampal neurons after sleep deprivation
- VernacularTitle:MAPKs在睡眠剥夺大鼠海马神经元内表达变化的研究
- Author:
Qian ZHANG
;
Jiangtao CHENG
;
Shuchun WANG
;
Peng QIAO
;
Yiling WANG
;
Jinglan WU
;
Yuruo WANG
- Publication Type:Journal Article
- Keywords:
Sleep deprivation;
Apoptosis;
Rats;
Mitogen-activated protein kinases
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the change and the possible role of MAPKs in rat hippocampus neuron after sleep deprivation. METHODS: The morphology of hippocampus neuron after sleep derivation was observed by TUNEL and HE staining, the activity of ERK was assayed by ?-liquid scintillation counting and the expression of JNK was detected by Western blot. RESULTS: In paradoxical sleep deprivation (PSD) group, the number of apoptotic cells in hippocampus was increased. The scores of ERK activity were (1 764.00)?941.56. Compared with control groups, the ERK activity was obviously decreased (P
