Changes in concentration of amino acids in newborn rabbits brain with hyperbilirubinemia
- VernacularTitle:高胆红素血症新生兔脑组织中氨基酸含量的变化及意义
- Author:
Jie LU
;
Tao GUO
- Publication Type:Journal Article
- Keywords:
Hyperbilirubinemia;
Rabbits;
Brain injuries;
Na(+)-K(+)-exchanging ATPase;
Amino acid neurotransmitters
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study whether the excitatory amino acids (EAAs)-triggered excitotoxicity contribute to the evolution of hyperbilirubinemia-associated brain injury. METHODS: Newborn rabbits with hyperbilirubinemia were decapitated and then, Na~+-K~+-ATPase activities, neurotransmitters and non-neurotransmitters concentration in brains were determined. RESULTS: It was found that the activities of Na~+-K~+-ATPase both in brains and cytomembrane and the amounts of glutamate (P
