PEG-4000 electrolyte lavage solution in endoscopy preparation, a multicenter randomized controlled study
- VernacularTitle:复方聚乙二醇用于内镜检查前结肠准备的多中心随机对照临床研究
- Author:
Liya ZHOU
;
Yunsheng YANG
;
Yaozong YUAN
- Publication Type:Journal Article
- Keywords:
PEG-4000 electrolyte;
Colonoscopy;
Colonic preparation
- From:
Chinese Journal of Digestive Endoscopy
1996;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To verify and evaluate the efficacy and safety of PEG-4000 electrolyte lavage solution in endoscopy preparation. Methods A multicenter open randomized controlled clinical study of 211 patients taking PEG-4000 electrolyte or mannitol in colonoendoscopy preparation. The overall evaluation of colonic preparation was the primary efficacy criterion. The investigator recorded any adverse event to assess the safety. Results The total effective rate of overall colonic preparation of study group was 92. 45% (98/ 106) , that of mannitol group was 80% (84/105). The study group showed more effective than control group with statistical significance (P = 0.016). The adverse event incidence of study group was 8.49%. There were 6 patients complained of nausea and vomiting, 3 patients showed abnormal laboratory results after administration. All the events relieved in short period and have no influence on examination. There was no serious adverse event in this group. The incidence of adverse event in mannitol group was 14. 29% (15/105 ). Four patients showed gastrointestinal symptoms and 1 showed chest suppression. Abnormal laboratory results were found in 10 patients. There was 1 serious adverse event occurred in control group. The difference between 2 groups had no statistical significance. Conclusion PEG-4000 electrolyte is a safe and effective drug in colonic preparation before clinical colonic examination or surgery.
