The Differential Expression of p53,VEGF and MVD in Breast Cancer and Tumor Adjacent Tissues and Its Clinical Significance
- VernacularTitle:乳腺癌和癌旁组织中p53、VEGF与MVD的差异表达及其临床意义
- Author:
Heping PENG
;
Hao GUAN
;
Helong XIAO
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Immunohistochemistry;
p53;
VEGF;
MVD
- From:
Journal of Chinese Physician
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expressions of p53, vascular endothelial growth factor (VEGF) and microvessel density (MVD) in breast cancer and tumor adjacent tissues to explore their relationship and roles in the pathogenesis of breat cancer. Methods The expression levels of p53,VEGF and MVD were assessed in 110 cases of breast cancer and tumor adjacent tissues with SP immunohistochemical method. Results The positive expression rate of VEGF and p53 was 90.0%(99/110) and 42.7%(47/110) in the breast cancer tissues, and 35.5%(39/110) and 4.5%(5/110) in the tumor adjacent tissues, respectively, which had highly significant difference between two groups (P
