Expression and Significance of Survivin and PCNA in Human Colorectal Carcinoma
- VernacularTitle:生存素mRNA、生存素和PCNA在大肠癌中的表达及意义
- Author:
Qingchun LIANG
;
Xianyang MI
;
Xinmin ZHANG
- Publication Type:Journal Article
- Keywords:
Colorectal carcinoma;
Survivin mRNA;
Survivin;
PCNA
- From:
Journal of Chinese Physician
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression and significance of survivin and PCNA in human colorectal carcinoma. Methods Using in situ hybridization and immunohistochemistry(S-P method) respectively to detect survivin mRNA, and survivin and PCNA proteins in 64 cases of colorectal carcinoma. Results The survivin expression wasn't detected in the tumor adjancent tissues. The positive rate of survivin mRNA and protein expressions was 53% and 53% respectively, which was significantly associated with the histological type and lymph node metastasis of colorectal carcinoma (P
