Value of urinary nucleosides determination for the diagnosis of colorectal carcinoma
- VernacularTitle:尿核苷检测对结直肠癌诊断价值的临床研究
- Author:
Minhua ZHENG
;
Bo FENG
;
Aiguo LU
;
Yufang ZHENG
;
Zhihai MAO
;
Junjun MA
;
Guowang XU
- Publication Type:Journal Article
- Keywords:
Colorectal carcinoma;
Nucleosides;
High performance liquid chromatography;
Analysis
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate urinary nucleosides determination for the diagnosis of colorectal carcinoma. Methods The concentrations of 14 different urinary nucleosides from 42 colorectal carcinoma patients, 10 patients with villous adenoma and 62 normal adults were determined by high-performance liquid chromatography (HPLC); Principal component analysis was applied to classify colorectal cancer patients and normal adults. Results The levels of Pseu、 C、 m1A、 mU、 m22G、 I、 m1G、 ac4C、 m6A in colorectal carcinoma group were (42.67?21.89)、(0.44?0.51)、(2.72?0.83)、(0.13?0.08)、(1.79?0.55)、(0.50?0.36)、(1.44?0.52)、(0.82?0.30)、(0.07?0.08)nmol/(?mol creatinine) respectively, which were much higher than those in normal adults (P
