Expression of Activated ERK and p38 Kinase in HPV-Infected Keratinocytes
- VernacularTitle:尖锐湿疣患者角质形成细胞中活化型细胞外信号调控蛋白激酶和活化型p38的检测
- Author:
Ming SU
;
Hao CHENG
;
Caixia SHENG
;
Nengding WU
;
Ling LI
;
Lijian XIANG
;
Yafen LI
;
Jianbo ZHONG
- Publication Type:Journal Article
- Keywords:
Condylomata acuminata;
Papillomavirus, human;
Mitogen-activated protein kinase kinases;
p38
- From:
Chinese Journal of Dermatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of activated ERK (p-ERK) and activated p38 (p-p38) in the keratinocytes of condyloma acuminata (CA) lesions. Methods Fifty cases of HPV 6/11 CA were diagnosed by in situ hybridization. The expression and distribution of p-ERK and p-p38 in CA lesions and 25 normal human skins (foreskins) were detected by immunohistochemistry technique (En Vision). Results ①The results showed that the expression of p-ERK and p-p38 in keratinocytes of CA lesions were significantly higher than those in normal epidermis (P
