Expression of Membrane Type 1 Matrix Metalloproteinase and Matrix Metalloproteinase-2 in Cutaneous Squamous Cell Carcinoma and Basal Cell Epithelioma
- VernacularTitle:皮肤鳞状细胞癌和基底细胞上皮瘤膜型基质金属蛋白酶-1、基质金属蛋白酶-2表达
- Author:
Zelin MA
;
Yiming FAN
;
Zhihua WU
;
Shunfan LI
- Publication Type:Journal Article
- Keywords:
Carcinoma, squamous cell;
Carcinoma, basal cell;
Matrix metalloproteinases
- From:
Chinese Journal of Dermatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe expression of membrane-type 1 matrix metalloproteinase-1 (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) and its relation to clinicopathological characteristics in cutaneous squamous cell carcinoma (SCC) and basal cell epithelioma (BCE). Methods The expression of MT1-MMP and MMP-2 was determined in situ hybridization and ABC immunohistochemical technique respectively in 48 cutaneous SCCs and 41 BCEs. Results The expression of MT1-MMP and MMP-2 in SCC was significantly higher than that in BCE (P 0.05). Conclusions Overexpression of MT1-MMP and MMP-2 might be related to lymphatic metastasis in SCC. Expression levels of MT1-MMP and MMP-2 may not be responsible for the differentiation in aggressiveness of BCE.
