Expression of CD28/B7 in the Lesional Skin and Peripheral Lymphocytes in Psoriasis
- VernacularTitle:CD28/B7在银屑病皮损及外周血淋巴细胞中的表达
- Author:
Changzheng HUANG
;
Aijun CHEN
;
Yating TU
;
Zhixiang LIU
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Antigens, CD28;
Antigens, CD80;
Antigens, CD86
- From:
Chinese Journal of Dermatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of costimulatory molecules CD28/B7 in the pathogenesis of psoriasis. Methods The expression of CD28, CD80 and CD86 was detected in the lesional skin of 22 cases by immunohistochemical technique (ABC), and in the peripheral blood lymphocytes of 17 cases by flow cytometry respectively. As control, normal skin and lymphocytes from peripheral blood of healthy volunteers were also tested. Results The immunohistochemistry study showed that the expression of CD28, CD80 and CD86 in the psoriatic lesions was significantly higher than that in the normal controls (P .05). Conclusion CD28, CD80 and CD86 might play a certain role in the pathogenesis in psoriasis.
